{"id":22,"date":"2018-08-27T03:53:08","date_gmt":"2018-08-27T03:53:08","guid":{"rendered":"http:\/\/leadinglifetechnologies.com\/?page_id=22"},"modified":"2026-05-06T10:42:50","modified_gmt":"2026-05-06T17:42:50","slug":"science-technology","status":"publish","type":"page","link":"https:\/\/leadinglifetechnologies.com\/?page_id=22","title":{"rendered":"Technology"},"content":{"rendered":"<p>Sensitive, specific and accurate determination of an analyte or biomarker is critical for diagnosis, therapy, drug &amp; vaccine safety. However, the complex nature of sample matrices poses a challenge to obtaining a reliable result, especially for those analytes and biomarkers with low abundance but high significance. For example, IgE-mediated anaphylaxis is life-threatening. Detection of pre-existing allergen-specific IgE can identify individuals at risk.\u00a0 By removing the internal background of each analyte, our proprietary FocalTuning\u2122 platform and products (<strong>US10,914,731B2, 2021; US11,835,517B2, 2023; ZL202080015982.5, 2024<\/strong>) can detect and quantify low level analytes such as polyethylene glycol\u00a0 (PEG) specific IgE, which has received increasing attention in severe hypersensitivity reactions of PEG and PEG-containing products, including food, cosmetics, daily life products, mRNA vaccines and PEGylated drugs. This general platform can also be applied to the early diagnosis of various diseases including cancer.\u00a0<\/p>\n\n\n<p class=\"wp-block-paragraph\">The features of\u00a0 FocalTuning\u2122 platform<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Patented technology<\/li>\n\n\n\n<li>Paired internal control design<\/li>\n\n\n\n<li>Two-level background correction<\/li>\n\n\n\n<li>Patient-specific background corrected<\/li>\n\n\n\n<li>Matrix-specific background corrected<\/li>\n\n\n\n<li>High sensitivity and accuracy <\/li>\n\n\n\n<li>Ability to multiplex <\/li>\n\n\n\n<li>Powerful statistics<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Sensitive, specific and accurate determination of an analyte or biomarker is critical for diagnosis, therapy, drug &amp; vaccine safety. However, the complex nature of sample matrices poses a challenge to obtaining a reliable result, especially for those analytes and biomarkers with low abundance but high significance. For example, IgE-mediated anaphylaxis is life-threatening. Detection of pre-existing &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/leadinglifetechnologies.com\/?page_id=22\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Technology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-22","page","type-page","status-publish","hentry"],"jetpack-related-posts":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22"}],"version-history":[{"count":145,"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":4005,"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=\/wp\/v2\/pages\/22\/revisions\/4005"}],"wp:attachment":[{"href":"https:\/\/leadinglifetechnologies.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}